Education:

B.S./M.S., Bucknell University, 1972
Ph.D., Harvard University, 1976

Research Interests:

My research group is interested in organic synthesis, broadly defined. Discovery of new synthetic reactions or the development of new synthesis strategies is often then applied to the construction of natural products (e.g., antitumor and cell-signaling agents), to the preparation of analogs or prodrugs of biologically active compounds (e.g., antiangiogenic peptidomimetics), and to the design and preparation of new materials (e.g., polymer synthesis and molecular electronics). We also investigate mechanistic aspects of the reactions we develop. Symmetry concepts are frequently an underlying theme and organometallic chemistry (e.g., olefin metathesis and metal-carbene chemistry) often plays an important role in our work. Finally, stereochemistry and structure are of interest--we are particularly interested in developing new NMR-based strategies for the assignment of absolute and relative configuration (e.g., of common natural product substructures and/or of newly isolated natural products themselves).

Publications:

"Relay Ring Closing Metathesis (RRCM): A Strategy for Directing Metal Movement Throughout Olefin Metathesis Sequences," Hoye, T. R.; Jeffrey, C. S.; Tennakoon, M. A.; Wang, J.; Zhao, H. J. Am. Chem. Soc. 2004, in press.

"Controlled Synthesis of High Molecular Weight Telechelic Polybutadienes by Ring Opening Metathesis Polymerization," Ji, S.; Hoye, T. R.; Macosko, C. W. Macromolecules 2004, ASAP.

Coupling Reactions of End- vs Mid-Functional Polymers, Jeon, J. H.; Macosko, C. W.; Moon, B.; Hoye, T. R.; Yin, Z. Macromolecules 2004, 37, 2563-2571

No-D NMR Spectroscopy as a Convenient Method for Titering Organolithium (RLi), RMgX, and LDA Solutions, Hoye, T. R.; Eklov, B. M. Org. Lett. 2004, 6, 2567-2570.

Synthesis and reactive blending of amine and anhydride end-functional polyolefins, Jones, T. D.; Macosko, C. W.; Moon, B.; Hoye, T. R. Polymer 2004, 45, 4189-4201.

No-D NMR (No Deuterium Proton NMR) Spectroscopy: A Simple Yet Powerful Method for Analyzing Reaction and Reagent Solutions," Hoye, T. R.; Eklov, B. M.; Ryba, T. D.; Voloshin, M.; Yao, L. J. Org. Lett. 2004, 6, 953-956.

Negative Differential Resistance in a Bilayer Molecular Junction," Le, J. D.; He, Y.; Hoye, T. R.; Mead, C. C.; Kiehl, R. A. App. Phys. Lett. 2003, 83, 5518-5520.

Design of a Partial Peptide Mimetic of Anginex with Antiangiogenic and Anticancer Activity, Mayo, K. H.; Dings, R. P. M.; Flader, C.; Nesmelova, I.; Hargittai, B.; van der Schaft, D. W. J.; van Eijk, L. I.; Walek, D.; Haseman, J.; Hoye, T. R.; Griffioen, A. W. J. Biol. Chem. 2003, 278, 45746-45752.

Macrolactonization via Ti(IV)-Mediated Epoxy-Acid Coupling: A Total Synthesis of (-)-Dactylolide [and Zampanolide], Hoye, T. R.; Hu, M. J. Am. Chem. Soc. 2003, 125, 9576-9577.

Cytotoxic Hydroazulene Diterpenes from the Brown Alga Cystoseira myrica," Ayyad, S. N.; Abdel-Halim, O. B.; Shier, W. T.; Hoye, T. R. Zeitschrift für Naturforschung C 2003, 58, 33-38.

"Synthesis and Application of Fluorescently Labeled Phthalic Anhydride (PA) Functionalized Polymers by ATRP, Moon, B.; Hoye, T. R.; Macosko, C. W. Polymer 2002, 43, 5501-5509.

Toward Computing Relative Configurations: 16-epi-Latrunculin B, a New Stereoisomer of the Actin Polymerization Inhibitor, Latrunculin B, Hoye, T. R.; Ayyad, S. N.; Eklov, B. M.; Hashish, N. E.; Shier, W. T.; El Sayed, K. A.; Hamann, M. T. J. Am. Chem. Soc. 2002, 124, 7405-7410.

Reactivity of Common Functional Groups with Urethane: Models for Reactive Compatibilization of Thermoplastic Polyurethane Blends," Lu, Q. W.; Hoye, T. R.; Macosko, C. W. Journal of Polymer Science: Part A: Polymer Chemistry 2002, 2310-2328.

A Method for Easily Determining Coupling Constant (J) Values: An Addendum to 'A Practical Guide to First-Order Multiplet Analysis in 1H NMR Spectroscopy', Hoye, T. R.; Zhao, H. J. Org. Chem. 2002, 67, 4014-4016.