Stephen Hecht

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Stephen Hecht, Ph.D.

Academic Title

Wallin Land Grant Professor of Cancer Prevention, Department of Laboratory Medicine and Pathology

Laboratory Medicine and Pathology (Graduate Faculty in Medicinal Chemistry)


Professor of Laboratory Medicine and Pathology
Masonic Cancer Center Professor
Graduate Faculty Medicinal Chemistry


Duke University
Massachusetts Institute of Technology
Other Education
PostDoc, Massachusetts Institute of Technology

Contact Info




Office Address

CCRB 2-148

Mailing Address

University of Minnesota
Masonic Cancer Center
2231 6th St SE
2-148 CCRB
Minneapolis, MN 55455

Bio Statement

The goal of research in the Hecht laboratory is to understand mechanisms of metabolic activation and DNA modification by carcinogens in tobacco products and the human environment, and apply this knowledge to cancer prevention. The laboratory focuses on the properties of carcinogenic nitrosamines, polycyclic aromatic hydrocarbons, and aldehydes. Using state of the art mass spectrometry and related techniques, analytical methods are developed for quantitation of carcinogen and toxicant metabolites and DNA adducts in laboratory animals treated with carcinogens and in human urine, blood and tissues. These biomarkers are applied in collaborative clinical and epidemiologic studies to investigate human carcinogen exposure, metabolism, and susceptibility to cancer. Stable isotope labeled carcinogens and their analogues are employed in studies with users of tobacco products to track individual differences in metabolism. The effects of naturally occurring potentially cancer chemopreventive compounds on carcinogen metabolism in humans are also investigated.

Research Interests

  • Tobacco
  • Carcinogens
  • Metabolism
  • DNA adducts
  • Biomarkers


1987-2001 Outstanding Investigator Grant, National Cancer Institute

2000-2009 American Cancer Society Research Professor

2001 Alton Ochsner Award Relating Smoking and Health

2002 Flight Attendant Medical Research Institute Dr. William Cahan Distinguished Professor

2004 Merit Award, National Cancer Institute

2006 Academy for Excellence in Health Research, Academic Health Center, University of


2006 AACR Cancer Research and Prevention Foundation Award for Excellence in Cancer
Prevention Research

2009 Founders Award, Division of Chemical Toxicology, American Chemical Society

2009 Elected American Chemical Society Fellow

2012 Joseph Cullen Award, American Society of Preventive Oncology

2012 Selected as Editor-in-Chief, Chemical Research in Toxicology

2014 Elected American Association for the Advancement of Science Fellow


NCBI Bibliography

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  • Last modified on January 8, 2015