Education:

B.A., Northwestern University, 1967
M.S., University of Iowa, 1970
Ph.D., University of Minnesota, 1973

Research Interests:

The design, synthesis, and practical applications of new biomaterials, especially those containing carbohydrates are a major focus research in the Gleason laboratory.  Our group is multidisciplinary and includes both chemists and engineers.  Applications of current interest include materials for the delivery of therapeutic agents, including “micro” and macro-molecules. Structure determination of molecules of biological importance using X-ray crystallography are also undertaken. Examples of work in this area include: solid-state pharmaceutical chemistry, peptidomimetics, steroids, carcinogens, HIV-protease inhibitors, and model systems for understanding protein/ligand recognition.  Research in our laboratory is also concerned with computational biology with an emphasis on structure-based computer modeling of systems of biomedical relevance.  We are actively engaged in drug docking studies of kinases and of heparin-binding proteins such as growth factors, cytokines, and proteins involved in blood coagulation.  

Publications:

Stanek, L. G.; Heilmann S. M.; Gleason, W. B. Preparation and Copolymerization of a Novel Carbohydrate Containing Monomer, Carbohydrate Polymers, (Article in Press, available electronically).

Stanek L. G.; Heilmann, S. M._­­;Gleason, W. B.  Preparation of Monodisperse PMMA Microspheres Using 2-Vinyl-4,4?-Dimethylazlactone as a Particle Stabilizer. Colloid Polymer Science. 99, 586-595 (2006).

Stanek, L. G., S. M. Heilmann, and W. B. Gleason, Synthesis and Monomer Reactivity Ratios of Methyl Methacrylate and 2-Vinyl-4,4'-dimethylazlactone Copolymers at Low and High Conversion, Journal of Polymer Science: Part A: Polymer Chemistry 41, 3027-3037 (2003).

Britton, D.; Gleason, W. B. Diiododurene: four centrosymmetric molecules in general positions. Acta Crystallographica - Section C - Crystal Structure Communications 59(Part 8): O439-O442 (2003).

Ojala, C. R.; Ojala, W. H.; Gleason, W. B.; Britton, D.   The Crystal Structures of p-halo-N-(p-cyanobenzylidene)aniline and p-cyano-N-(p-halobenzylidene) aniline (Halo = Bromo and Chloro), Journal of Chemical Crystallography 31, 377-386 (2002).

Britton, D.; Gleason, W. B.  Dicyanodurene-p-tetrafluorodiiodobenzene (1/1), Acta Crystallographica E58, 1375-1377 (2002).

Johnson, E. R.;Gleason, W. B.  Molecular Dynamics Simulations of Heparin. 1. New Parameters for Sulfated Carbohydrates Suitable for Use with NAMD, Research Report, Supercomputing Institute for Digital Simulation and Advanced Computation 2002/94, 1-25 (2002).

Eccleston, E.; Johnson, E.; Chaurushiya, M; Zhang, Runesha, S.; Gleason, W. B.  Parallel Computing Strategies for the Interpretation of Mass Spectral Data for Proteomics Applications, Research Report, Supercomputing Institute for Digital Simulation and Advanced Computation 2001/161, 1-17 (2001).

Zhou, B.; Nelson, T. R.; Kashtan, C.; Gleason, W. B; Michael, A. F; Vlassi, M.; Charonis, A. S. Identification of Two Alternatively Spliced Forms of Human Tubulointerstitial Nephritis Antigen (TIN-Ag).  Journal of the American Society of Nephrology 11, 658-68 (2000).