Gunda Georg, Ph.D.
Professor and Head
Robert Vince Endowed Chair
McKnight Presidential Chair in Medicinal Chemistry
Director - Institute for Therapeutics Discovery & Development
1975, Philipps Universität Marburg, Germany
1980, Philipps Universität Marburg
Postdoctoral 1981, Philipps Universität Marburg & Postdoctoral 1982, University of Ottawa, Canada
717 Delaware St SE, Room 452
University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
717 Delaware St. SE
Minneapolis, MN 55414
Professor Georg and her group have published 180 scientific articles and are involved in the design, semisynthesis, total synthesis, and evaluation of biologically active agents. Current therapeutic areas include cancer, male contraception, epilepsy, and Alzheimer's disease. These projects require the development of synthetic methods, synthesis of natural products, and structure-activity studies aimed at improving the therapeutic efficacy of lead compounds, including natural products, and hits from high throughput screening.
Interdisciplinary projects are a main focus in the Georg group, involving medicinal chemistry, biochemistry, pharmacology, pharmaceutical chemistry and reproductive biology. Active collaboration exists between the Reproductive Branch of the National Institute of Child Health and Human Development, the Chemical Biology Consortium of the National Cancer Institute, several research groups at the University of Minnesota, and around the country. Professor Georg is the co-inventor of LusedraTM, which is marketed by Eisa Pharmaceuticals. She is also a co-inventor of Minnelide, an anticancer agent in phase I clinical trials, and of Gamedazol, a male contraceptive agent in preclinical development.
Stella, V.; Krise, J.; Zygmunt, J. J.; Georg, G. I. Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof.
Stella, V.; Zygmunt, J. J.; Georg, G.I.; Safadi, M. S. Water-soluble prodrugs of hindered alcohols.
Georg, G. I.; Tash, J.; Chakrasali, R.; Jakkaraj, S. R. Lonidamine Analogues and their Use in Male Contraception and Cancer Treatment.
Michaelis, M. L.; Georg, G. I.; Himes, R. H.; Audus, K. Neuroprotective Agents.
Georg, G. I.; Saluja, A,; Patil, S. Vickers, S.; Chugh, R. Triptolide Prodrugs (patent pending).
- synthetic medicinal agents
- natural products chemistry
- new synthetic methods
Professor Georg is the co-Editor-in-Chief of the Journal of Medicinal Chemistry of the American Chemical Society. She has served as a member of review panels for the National Institutes of Health, the National Science Foundation, the American Cancer Society and others. She is a Fellow of the American Association for the Advancement of Science. She was the 2000 Sato Memorial International Award recipient of the Pharmaceutical Society of Japan and the 2001 Nolan and Gloria Sommer Award Winner (University of Nebraska). Named Lectures: 2005 Loyd E. Harris Lecturer of the School of Pharmacy, University of Oklahoma, 2005 Taito O. Soine Lecturer in Medicinal Chemistry at the University of Minnesota, 2005 George Lesher Lecturer in Bioorganic and Medicinal Chemistry in the Department of Chemistry at the Rensselear Polytechnic Institute. 2007 Stanford Distinguished Women in Science Colloquium. 2008 Pharmacological and Pharmaceutical Sciences Distinguished Lecture. University of Houston College of Pharmacy, 2009 Ohio State University, College of Pharmacy Distinguished Lecture Series, 2010 Henry A. Lardy Lecture, South Dakota State University Department of Chemistry, 2010 Sosnovsky Distinguished Lectureship,University of Wisconsin-Milwaukee, Department of Chemistry.
Tash. J. S.; Attardi, B.; Hild, S. A.; Chakrasali, R.; Jakkaraj, S. R.; Georg, G. I. A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and is Contraceptive in
Rats after a Single Oral Dose. Biology of Reproduction 2008, 78, 1127-1138.
Desino, K. E.; Ansar, S.; Georg, G. I.; Himes, R. H.; Michaelis, M. L.; Powell, D. R.; Reiff, E. A.; Telikepalli, H.; Audus, K. L. (3R,5S,7as)-(3,5-bis(4-Fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl) methanol: A Novel Neuroprotective Agent. J. Med. Chem. 2009, 52, 7537-7543.
Reiff, E. A.; Nair, S. N.; Henri, J. T.; Greiner, J. F.; Reddy, B. S.; Chakrasali, R.; David, S.;Chiu, T.-L.; Amin, E. A.; Himes, R. H.; VanderVelde, D. G.; Georg, G. I. Total Synthesis and
Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin. J. Org. Chem. 2010, 75, 86-94.
Niphakis, M. J.; Georg, G. I. Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling. Org. Lett. 2011, 13, 196-199.