INDEPENDENT PUBLICATIONS
16. Venkatraman, L.; Salomon, C. E.; Sherman, D. H.; Fecik, R. A. Total Synthesis of Narbonolide and Biotransformation to Pikromycin. J. Org. Chem. 2006, 71, 9853–9856.
15. Akey, D. L.; Kittendorf, J. D.; Giraldes, J. W.; Fecik, R. A.; Sherman, D. H.; Smith, J. L. Structural Basis for Macrolactonization by the Pikromycin Thioesterase. Nat. Chem. Biol. 2006, 2, 537–542.
14. Giraldes, J. W.; Akey, D. L.; Kittendorf, J. D.; Sherman, D. H.; Smith, J. L.; Fecik, R. A. Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels. Nat. Chem. Biol. 2006, 2, 531–536.
13. Fecik, R. A.; Nguyen, P. L.; Venkatraman, L. Approaches to the Synthesis of Immunolides: Selective Immunomodulatory Macrolides for Cystic Fibrosis. Curr. Opin. Drug Disc. Dev. 2005, 8, 741–747.
12. Venkatraman, L.; Aldrich, C. C.; Sherman, D. H.; Fecik, R. A. Formal Total Synthesis of the Polyketide-derived Macrolactone Narbonolide. J. Org. Chem. 2005, 70, 7267–7272.
11. Aldrich, C. C.; Venkatraman, L.; Sherman, D. H; Fecik, R. A. Chemoenzymatic Synthesis of the Polyketide Macrolactone 10-Deoxymethynolide. J. Am. Chem. Soc. 2005, 127, 8910–8911.
10. Aldrich, C. C.; Beck, B. J.; Fecik, R. A.; Sherman, D. H. Biochemical Investigation of Pikromycin Biosynthesis Employing Native Penta- and Hexaketide Chain Elongation Intermediates. J. Am. Chem. Soc. 2005, 127, 8441–8452.
9. Beck, B. J.; Aldrich, C. C.; Fecik, R. A.; Reynolds, K. A.; Sherman, D. H. Substrate Recognition and Channeling of Monomodules from the Pikromycin Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 12551–12557.
8. Beck, B. J.; Aldrich, C. C.; Fecik, R. A.; Reynolds, K. A.; Sherman, D. H. Iterative Chain Elongation by a Pikromycin Monomodular Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 4682–4683.
POSTDOCTORAL PUBLICATIONS
7. Boger, D. L.; Miyauchi, H.; Du, W.; Hardouin, C.; Fecik, R. A.; Cheng, H.; Hwang, I.; Hedrick, M. P.; Leung, D.; Acevedo, O.; Guimarães, C. R. Q.; Jorgensen, W. L.; Cravatt, B. F. Discovery of a Potent, Selective, and Efficacious Class of Reversible a-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics. J. Med. Chem. 2005, 48, 1849–1856.
6. Fedorova, I.; Hashimoto, A.; Fecik, R. A.; Hedrick, M. P.; Hanus, L. O.; Boger, D. L.; Rice, K. C.; Basile, A. S. Behavioral Evidence for the Interaction of Oleamide with Multiple Neurotransmitter Systems. J. Pharmacol. Exp. Ther. 2001, 299, 332–342.
5. Boger, D. L.; Fecik, R. A.; Patterson, J. E.; Miyauchi, H.; Patricelli, M. P.; Cravatt, B. F. Fatty Acid Amide Hydrolase Substrate Specificity. Bioorg. Med. Chem. Lett. 2000, 10, 4645–4648.
4. Boger, D. L.; Sato, H.; Lerner, A. E.; Hedrick, M. P.; Fecik, R. A.; Miyauchi, H.; Wilkie, G. D.; Austin, B. J.; Patricelli, M. P.; Cravatt, B. F. Exceptionally Potent Inhibitors of Fatty Acid Amide Hydrolase. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 5044–5049.
GRADUATE PUBLICATIONS
3. Fecik, R. A.; Devasthale, P.; Pillai, S.; Keschavarz-Shokri, A.; Shen, L.; Mitscher, L. A. Chiral DNA Gyrase Inhibitors. 3. Probing the Chiral Preference of the Active Site of DNA Gyrase. Synthesis of 10-Fluoro-6-methyl-6,7-dihydro- 9-piperazinyl-2H-benzo[ a]quinolizine-20-one-3-carboxylic Acid Analogues. J. Med. Chem. 2005, 48, 1229–1236.
2. Fecik, R. A.; Frank, K. E.; Gentry, E. J.; Mitscher, L. A.; Shibata, M. Use of Combinatorial and Multiple Parallel Synthesis Methodologies for the Development of Anti-Infective Natural Products. Pure Appl. Chem. 1999, 71, 559–564.
1. Fecik, R. A.; Frank, K. E.; Gentry, E. J.; Menon, S. J.; Mitscher, L. A.; Telikepalli, H. The Search for Orally Active Medications through Combinatorial Chemistry. Med. Res. Rev. 1998, 18, 149–185.
