Esam El-Fakahany, Ph.D.
Associate Dean for Research and Graduate Studies
Experimental and Clinical Pharmacology
Pharmacy, University of Alexandria, Alexandria, Egypt
M.S. Pharmacology, Alexandria University, Alexandria, Egypt
Pharmacology, University of Minnesota, Mayo Graduate School, Rochester, MN
7-101 Weaver-Densford Hall
University of Minnesota
College of Pharmacy
Department of Experimental and Clinical Pharmacology
7-115 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455
Dr. El-Fakahany's research interests are focused in the areas of neuronal receptor modulation, mechanisms of receptor coupling to second messenger signal transduction pathways, and Alzheimer's disease. One of the main ongoing research areas is the investigation of the cellular pathways that link muscarinic acetylcholine receptors to the generation of nitric oxide in neurons, particularly in relation to hydrolysis of membrane phospholipids and calcium signaling. The laboratory is also interested in elucidating the mechanisms of feedback regulation of nitric oxide. Nitric oxide plays major roles in the regulation of cerebral blood flow, memory and neurotoxicity. Another area of interest is the investigation of the molecular mechanisms of action of drugs used for the treatment of Alzheimer's dementia. All of these questions are addressed by applying a combination of pharmacological and molecular biology techniques in mammalian brain, cultured neurons, or genetically engineered cells.
- Alzheimer's therapy
- Cholinergic replacement therapy for Alzheimer's
Associate Dean for Research and Graduate Education
Cabadak, H., A.E. Cuadra, E.E. El-Fakahany and B. Kan @. M2, M3 and M4 muscarinic receptors are expressed in the guinea-pig gallbladder. Journal of Receptors and Signal Transduction, 29: 63–66, 2009.
Noetzel, M.J., M.K.O. Grant and E.E. El-Fakahany @. Immediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor. Neurochemical Research, 34:1138-1149, 2009
Michal, P., V. Rudajev, E.E. El-Fakahany, V. Doležal@..Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways. European Journal of Pharmacology, 606: 50-60, 2009.
Noetzel, M.J., M.K.O. Grant and E.E. El-Fakahany @. Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding. Pharmacology, 83: 301-317, 2009.
Jakubík, J. @, A. Randáková, E.E. El-Fakahany and V. Dolezal. Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors. BioMed Central Pharmacology, 9 (15), 1-20, 2010.
Jakubik, J. @ and E.E. El-Fakahany. Allosteric Modulation of Muscarinic Acetylcholine Receptors. Pharmaceuticals, 3, 2838-2860, 2010.
Grant, M.K.O, K. De Lorme, M. Noetzel, J. Jakubik, V. Dolezal and E.E. El-Fakahany @. Pharmacological evaluation of the long-term effects of xanomeline on the M1 muscarinic acetylcholine receptor. PLoS ONE, e15722, Dec. 23; 5(12), 2010.
Jakubík J., H Janíčková, EE El-Fakahany and V Doležal @. Negative cooperativity in binding of muscarinic receptor agonist and GDP as a measure of agonist efficacy. British Journal of Pharmacology, 162: 1029-1044, 2011.
Jakubik, J., A. Randakova, E.E. El-Fakahany and V. Dolezal @. Subtype differences in pre-coupling of muscarinic acetylcholine receptors, PLoS ONE, 6(11): e27732, 2012.
Janíčková H., V. Rudajev, P. Zimčík, J. Jakubík, H. Tanila, E.E. El-Fakahany, and V. Dolezal @. Uncoupling of M1- muscarinic receptor- G protein interaction by amyloid β1-42. Neuropharmacology, in press.
Weber-Main AM, E.E. El-Fakahany, J. Shanedling and G. Huibregtse. Optimizing the Practice of Mentoring: An online curriculum for the professional development of research mentors. 2012 Available at: http://www.ctsi.umn.edu/education/Mentoring/index.htm