Alumni

Michael Grillo (PhD), “Discovery of Ligands Targeting the DNA Mutator APOBEC3B using Fragment-based Drug Discovery” Advisor: Dr. Daniel Harki

Alexander Hurben (PhD), “Developing Chemical Tools to Map Molecular Mechanisms that Drive Disease” Advisor: Dr. Natalia Tretyakova

Garrett Schey (PhD), “Exploring and Exploiting the Substrate Selectivity of Farnesyltransferase” Advisor: Dr. Mark Distefano

Caroline Buchholz (PhD), “Chemical Probe Development for Bromodomain and PHD Finger-containing Transcription Factor (BPTF) Reader Domains as Anti-Cancer Therapy” Advisor: Dr. William Pomerantz

Jacob Bouchard (PhD), “Discovery of Potent and Selective Melanocortin Receptor Ligands” Advisor: Dr. Carrie Haskell-Luevano

Samantha Kennelly (PhD), “Synthesis And Characterization Studies Of Nucleoside Analogues: Chemical Probes With Photochemically Controlled Properties And Phosphoramidate Pronucleotides As Antiviral Agents” Advisor: Dr. Daniel Harki

Maxwell Dillenburg (PhD), “Design, Synthesis, and Characterization of Nucleoside Based Probes to Evaluate the Role of Human Histidine Triad Nucleotide Binding Protein 1 in Mu Opioid Receptor and N-Methyl-D-Aspartate Receptor Cross Regulation” Advisor: Dr. Carston R. Wagner

Md Abdullah Al Noman (PhD), "Developing Contraceptives & Anticancer Agents: RAR Alpha Antagonists & Pironetin Analogs" Advisor: Dr. Gunda Georg

Peng Ge (PhD), "Development of Bioassays Engaging Principal Protein Targets in the Diagnostic and Mechanistic Studies of Parkinson's Diseases and Tuberculosis" Advisor: Dr. Courtney Aldrich

Nicole Mai Bentz (PhD), "Harnessing the Synergistic Self-Assembly of G-Quadruplex-Peptide Phosphoramidates: From Elucidating Assembly Mechanisms and Hydrogel Characteristics to Applications in Supramolecular Drug Delivery" Advisor: Dr. Carston Wagner

Nan Wang (PhD), "Development of CDK2 Allosteric Inhibitors for Male Contraception and Anti-cancer Therapy" Advisor: Dr. Gunda Georg

Conrad Fihn (PhD), "Development, Evaluation, and Optimization of Putative Histidine Kinase Inhibitors and Probes for Identification of Direct Cellular Targets in Pseudomonas aeruginosa and Beyond" Advisor: Dr. Erin Carlson

Malcolm Cole (PhD), "​Design, Synthesis, and Evaluation of Pyrazinoic Acid-Derived Antituberculars for Drug-Resistant Mycobacterium Tuberculosis" Advisor: Dr. Courtney Aldrich

An Yang (MS), “Development of Allosteric CDK2 Inhibitors as Non-hormonal Male Contraceptives and Cancer Therapeutics” Advisor: Dr. Gunda Georg

Caitlin Jokipii Kruger (PhD), “1,3-Butadiene-Induced DNA Damage: Ethnic Differences and Sources of Formation” Advisor: Dr. Natalia Tretyakova

Dmitri Konorev (PhD), “Biomonitoring Exposures to Environmental and Dietary Carcinogens by Targeted and Untargeted Mass Spectrometry” Advisor: Dr. Robert Turesky

Pooja Hedge (PhD), “Design And Development Of Antibiotics And Synthesis Of Modified Nucleosides” Advisor: Dr. Courtney Aldrich

Jian Tang (PhD), “Targeting Transcription Factors in Neuroblastoma: Development of Aurora Kinase A/N-Myc Degraders and ID2 Chemical Probes” Advisor: Dr. Daniel Harki

Mikki Twiggs (MS), “Synthesis and Fluorescence Characterization of a Small Library of N-phenyl-1-naphthylamine Derivatives” Advisor: Dr. Adam Duerfeldt

Scott Brody (PhD), “Proteomic Approaches for Profiling Cofactor-Dependent Proteins in Mycobacterium Tuberculosis” Advisor: Dr. Courtney Aldrich

Ellie Mews (PhD), "​Directing T Cells with Chemically Self-Assembled Nanorings as an Immunotherapy for Targeting Hematological Malignancies and Solid Tumors" Advisor: Dr. Carston R. Wagner

Kayla Vinh (MS), "Exploring Epigenetic Mechanisms of CBP/p300 and BRD4 Through Peptide and Small Molecule Inhibitors " Advisor: Dr. William Pomerantz

Damilola Ademola-Green (MS), "Towards the Discovery of Covalent APOBEC3G Ligands" Advisor: Dr. Daniel Harki

Joshua Shirley (PhD), "Development of Activity-Based Probes and Biochemical Methods for the Study of Penicillin-Binding Proteins in Live Bacteria" Advisor: Dr. Erin Carlson

William McCue (PhD), "Structural Studies to Enable Drug Discovery" Advisor: Dr. Barry Finzel

Analise Roth-Rodriguez (MS), "Synthesis of Aryl Substituted Acylpiperidines for the Inhibition of TNFR1" Advisor: Dr. David Ferguson

Connor McDermott (PhD), "New Chemical Matter from Extinct Life and for Extant Life: Paleopharmaceuticals and Bioterrorism Countermeasures" Advisor: Dr. Elizabeth Ambrose

Anand Divakaran (PhD), "Development and Cellular Evaluation of Selective N-Terminal BET Bromodomain Inhibitors" Co-Advisors: Dr. Daniel Harki and Dr. William Pomerantz

Erik Faber (PhD), "Development of Allosteric Inhibitors against Cyclin-dependent Kinase 2 (CDK2)" Advisor: Dr. Gunda Georg

Zoe Koerperich (PhD), "A Solution Towards Weight Management: Discovery, Design, Synthesis, and Characterization of Melanocortin Ligands" Advisor: Dr. Carrie Haskell-Luevano

John Schultz (PhD), "Development of Antibacterial Compounds to Target Drug Resistant Bacteria" Advisor: Dr. Courtney Aldrich

Jenna Thomforde (MS), "DNA-Protein Cross-links: Formation, Repair, and Inhibition of DNA Replication" Advisor: Dr. Natalia Tretyakova

Jiewei Jiang (PhD), "Part 1: Design and Synthesis of BRDT Selective Inhibitors as Male Contraceptive Agents Part 2: Focused Library Synthesis for TGR5 (Takeda G Protein-Coupled Receptor 5) Antagonist" Advisor: Dr. Gunda I. Georg

Xianghong Guan (PhD), "Discovery of Fluorescence Polarization Probes and Inhibitors for Testis-specific Bromodomain and Extra-Terminal (BRDT) Proteins" Advisor: Dr. Gunda I. Georg

Jenna Fernandez (PhD), "Epigenetic Mechanisms in Lung Cancer Development" Advisor: Dr. Natalia Tretyakova

Kellan Passow (PhD), "Synthesis and Evaluation of Novel Nucleoside Analogues: Development of Fluorescent, Bioorthogonal, and Antiviral Tool Compounds" Advisor: Dr. Daniel Harki

Alex Strom (PhD), "Kinetic and Structural Characterization of Human Histidine Triad Nucleotide Binding Enzymes" Advisor: Dr. Carston R. Wagner 

Evan Alexander (PhD), "Selective Inhibition of Virulence Factors in the Human Microbiota" Advisor: Dr. Courtney Aldrich 

Brian Gabet (MS), "Development Of Inhibitors For The Cation Channels Of Sperm For Male Contraception" Advisor: Dr. Gunda I. Georg

Özgün Kılıç (PhD), "Targeting EGFR family receptors with CSANs utilizing alternative protein scaffolds" Advisor: Dr. Carston R. Wagner  

Sara Coulup (PhD), "Synthesis and Evaluation of a Metabolically Stabilized Analog and Conjugates of Pironetin" Advisor: Dr. Gunda Georg

Harrison West (PhD), "Self-assembling Phosphoramidate Pronucleotides: Enzymatic Regulation and Application Towards Therapeutic Delivery" Advisor:  Dr. Carston R. Wagner 

Amanda Degner (MS), "Mass Spectrometry Based Analysis of Electrophile Induced Adducts of Biomolecules" Advisor: Dr. Natalia Tretyakova

Katlyn Fleming (PhD), "Development of Molecular Probes for the Central Melanocortin System" Advisor: Dr. Carrie Haskell-Luevano

Erick Carlson (PhD), "The Development of Potential Male Contraceptives Via Inhibition of Catsper and also GBA2" Advisor: Dr. Gunda Georg

Andrea Wisniewski (PhD), "Identification and Characterization of Potential BRDT(1) Inhibitors by Fragment-Based Screening Using Differential Screening Fluorimetry and Orthogonal Techniques" Advisor: Dr. Gunda Georg

Emily Boldry (MS), "Ethnic Differences in the Metabolism of 1,3-Butadiene and Lung Cancer Risk" Advisor: Dr. Natalia Tretyakova

Jillian Kyzer (PhD), "Design and Synthesis of Retinoic Acid Receptor Alpha Antagonists for Male Ccontraception" Advisor: Dr. Gunda Georg

Matthew Bockman (PhD), "Targeting Two Late-Stage Enzymes of the Mycobacterium tuberculosis Biotin Biosynthetic Pathway" Advisor: Dr. Courtney Aldrich

Christopher Seiler (PhD), "Epigenetic Mechanisms in Lung Cancer" Advisor: Dr. Natalia Tretyakova

Joseph Buonomo (PhD), "Selective Chemistry to Improve Organic Chemistry and Drug Discovery" Advisor: Dr. Courtney Aldrich

Clifford Csizmar (PhD), "Engineered Proteins for Studying and Controlling Cellular Recognition" Advisor: Dr. Carston R. Wagner

Aniekan Okon (PhD), "Development of Chemical Probes for Intracellular Nucleotide Delivery, Profiling of the Metabolic Fate(s) of Nucleoside Monoester Phosphoramidates, and A Nucleotide Mimetic Inhibitor of eIF4E" Advisor: Dr. Carston R. Wagner

Katerine Schlasner (MS), "Tetrapeptide Melanocortin Agonist Ligands Exploring Selectivity of the mMC3R Using DPhe Substitutions in the Ac-His-Arg-DPhe-Tic-NH2 Scaffold" Advisor: Dr. Carrie Haskell-Luevano

Arnold Groehler IV (PhD), "Mass Spectrometry-Based Characterization, Quantitation, And Repair Investigations Of Complex DNA Lesions" Advisor: Dr. Natalia Tretyakova

Trinh Holth (PhD), "Design and Synthesis of Natural Product Analogs of Stevioside and Synthetic Aanalogs of Retinoic Acid" Advisor: Dr. Gunda Georg

Jacob Petersburg (PhD), "Prosthetic Antigen Receptors as a Platform for Solid Tumor Immunotherapy" Advisor: Dr. Carston R. Wagner

Rachit Shah (PhD), "A New Target for Pain: Development of Tools to Study Human Histidine Triad Nucleotide Binding Proteins" Advisor: Dr. Carston R. Wagner

Cody Lensing (PhD), "Bivalent Ligands as Pharmacological Probes for The Melanocortin Receptors: The Bivalent Advantage" Advisor: Dr. Carrie Haskell-Luevano

Carter Eiden (PhD), "Room Temperature Chemoselective Phosphine Oxide Reduction and Mechanism-Based Inhibitors of BioA" Advisor: Dr. Courtney Aldrich

John Widen (PhD), "Design and Synthesis of Natural Product-Inspired, Cysteine Reactive Probes toward Inhibition of Transcription Factors and Target Identification Studies" Advisor: Dr. Daniel Harki

Denise Casemore (MS), "Chromene Based Compounds to Treat Multidrug Resistant Cancer" Advisor: Dr. Chengguo Xing

Skye Doering (PhD), "Discovery of Peptide and Peptidomimetic Based Ligands Targeting the Melanocortin Receptors: A Campaign in Mixture-Based Positional Scanning, Chemical Topology, and Structure-Activity Relationships" Advisor: Dr. Carrie Haskell-Luevano

William Fiers (PhD), "Biochemical Interrogation of Polyketide Ketoreductase and Dehydratase Domain Stereoselectivity, Stereospecificity and Mechanism via Synthetic, Truncated Substrates" Advisor: Dr. Robert Fecik

David Huang (PhD), "The Synthesis and Evaluation of Pironetin and Pironetin Analogs as Ovarian Cancer Chemotherapeutic Agents" Advisor: Dr. Gunda Georg

Kimberly Maize (PhD), "Structure Biology for Drug Design: Applications in Two System" Advisor: Dr. Barry Finzel

Jingjing Shen (PhD) (Chemistry), "Self-Assembled Antibody Nanorings as Prosthetic Antigen Receptors for Redirecting T Cells and as Platform for Co-delivery of Vaccine and Adjuvants for Cancer Immunotherapy" Advisor: Dr. Carston R. Wagner

Nicholas Struntz (PhD), "Synthesis of Photoresponsive Nucleosides and Their Incorporation into Oligonucleotides: Targeting Androgen Receptor and NF-kB Transcription Factors" Advisor: Dr. Daniel Harki

Adam Zarth (PhD), "Analyses of Detoxification and DNA Damage From the Human Carcinogens Benzene and N'-Nitrosonorni Cotine" Advisor: Dr. Stephen Hecht

Bo Zhou (PhD), "Chalcone-Based Chemical Probes as Versatile Tools for Potential Target Identification and Mechanism Elucidation of Chalcone's Bioactivities" Advisor: Dr. Chengguo Xing

Ran Dai (PhD), "Fragment based inhibitor design of Mycobacterium tuberculosis BioA" Advisor: Dr. Barry Finzel

Elbek K. Kurbanov (PhD), "Synthetic, Biochemical, C-ray Crystallographic, Computational and High-Throughput Screening Approaches Toward Anthrax Toxin Lethal Factor" Advisor: Dr. Elizabeth Ambrose

Yang Li (PhD), "Deciphering Cryptic Stereochemistry in Polyketide Biosynthesis and Functional Characterization of β-processing Domains in Pikromycin Synthase" Advisor: Dr. Robert Fecik

Li-Kai Liu (PhD), "Discovery of Small Molecule Inhibitors of Hyaluronan Binding at Cell Receptor CD44" Advisor: Dr. Barry Finzel

Margaret Olson (PhD), "High-Throughput Screening and Chemical Synthesis for the Discovery of APOBEC3 DNA Cytosine Deaminase Inhibitors" Advisor: Dr. Daniel Harki

Amit Gangar (PhD), "Self-Assembled Nanostructures For The Cellular Delivery Of Small Molecules, Oligonucleotides And Proteins For The Treatment Of Cancer" Advisor: Dr. Carston R. Wagner

Kwon Ho Hong (PhD), "Na,K-ATPase Alpha4 Isoform and HSP90 Molecular Chaperone as Molecular Targets for Drug Discovery" Advisor: Dr. Gunda Georg

Adwait Ranade (PhD), “Library Synthesis of Piperidinone Sulfonamides, Transition Metal-free C-H Trifluoromethylation of Cyclic Enaminones, and Elucidating the Binding Site of Epothilones on Beta-Tubulin with Epothilone Phtotoaffinity Probes” Advisor: Gunda Georg

Dewakar Sangaraju (PhD), "Mass Spectrometry Based Quantifications of 1, 3-Butadiene Induced DNA Adducts: Biomarkers of Cancer Risk” Advisor: Dr. Natalia Tretyakova

Susith Wickramaratne (PhD), “Biological Consequences of Complex DNA Lesions Induced by Bis-Electrophiles” Advisors: Drs. Natalia Tretyakova and Mark Distefano

Xia Zhang (PhD), "Experimental and Computational Methods for Identification of Novel Fungal Histone Acetyltransferase Rtt109 Inhibitors" Advisor: Dr. Elizabeth A. Ambrose

Timothy E. Andrews (MS), "Enhancing the Potency and Water Solubility of the Sesquiterpene Lactone Parthenolide" Advisor: Dr. Daniel Harki

Adam R. Benoit (PhD), "Synthesis and Evaluation of Acridine and Acridone Based Compound as Anti-Cancer and Anti-Bacterial Agents" Advisor: Dr. David Ferguson.

Nicholas P. Bleeker (MS), "Advancing a Novel Chemotype for the Treatment of Multidrug-Resistant Cancer" Advisor: Dr. Chengguo Xing

Kari A. Gabrielse (PhD), "Chemically Self-Assembled Antibody Nanorings: a Multifaceted Approach to Anti-Cancer Therapeutics Using Techniques Including Drug Delivery, Bispecific Targeting, and T Cell Surface Modification" Advisor: Dr. Carston R. Wagner

Srikanth Kotapati (PhD), "Mass Spectrometry-Based Analysis of Urinary Metabolites of 1,3-Butadiene (BD) in Humans and Influence of BD-DNA Adducts on DNA Replication" Advisor: Dr. Natalia Tretyakova

Rahul R. Lad (PhD), “Chemical and Biomolecular Structures in Recognition of DNA Modification” Advisor: Dr. Shana J. Sturla

Kathryn M. Nelson (PhD), "Synthesis and Evaluation of Tranvalencin Analogues and Adenylation Inhibitors as Antitubercular Agents and Chemical Probes" Advisor: Dr. Courtney Aldrich

Dan Wang (MS), "Synthesis and Evaluation of Parthenolide Analogues: Chemical Probes and Therapeutic Agents" Advisor: Dr. Daniel Harki

Bryant C. Gay (PhD), " Cyclic Enaminones: Synthons for Piperidine Containing Natural Products and Natural Product Analogs" Advisor: Dr. Gunda Georg

David Lampi Hermanson (PhD), "Mechanisms of CXL017: Targeting Drug Resistant Cancer" Advisor: Dr. Chengguo Xing

Shui Li (MS), "Evaluation of Eukaryotic Initiation Factor 4E (elF4E) Antagonist 4Ei-1 in Mammalian Breast Cancer and Lung Cancer Cells: Chemosensitization with Low Cytotoxicity" Advisor: Dr. Carston R. Wagner

Michael T. Peterson (PhD), "Design and synthesis of tubulysin analogs that stabilize and mimic a key acetate important for potent antiproliferative activity against multi-drug resistant cancers" Advisor: Dr. Robert A. Fecik

Martin B. Philips (PhD), "Characterization of the Chemical Properties of Intermediates in Furan Metabolism" Advisor: Lisa A. Peterson

Aaron Teitelbaum (PhD), "Pre-clinical Drug Development of 9-aminoacridines for Malignant Glioma and Meropenem Prodrugs for Drug-resistant Tuberculosis" Advisor: Dr. Rory P. Remmel

Sonia Das (PhD), “Developing Effective Anti-Cancer Agents that Target Drug-Resistant Malignancies” Advisor: Dr. Chengguo Xing

Xun Ming (MS), “DNA-protein cross-linking by CIS-1,1,2,2-diamminedichloroplatinum (II) (Cisplatin) formation of 8-OXO-dG and oxazolone lesions with p53 derived DNA sequences following photooxidation in the presence of riboflavin” Advisor: Dr. Natalia Tretyakova

Theresa Aliwarga (MS), “Clinical Pharmacokinetics Study of Phenytoin in Epilepsy Patients and Expression of Oxysterol 7alpha-Hydroxylase (hCYP7B1) in E. coli” Advisor Dr. Rory P. Remmel

Sanaa K. Bardaweel (PhD), “Defining the Catalytic and Kinetic Mechanism and Natural Function of the Highly Conserved Acyl-AMP Hydrolase, Hint1” Advisor: Dr. Carston R. Wagner

Qing Li (PhD), “Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic” Advisor: Dr. Carston R. Wagner

Erin Michaelson-Richie (MS), “DNA-Protein Cross-Linking by Bifunctional DNA Alkylating Agents” Advisor: Dr. Natalia Tretyakova

Jin Zhou (PhD), “Exploration on Atypical Kinetics of UGT1A1 and UGT1A4” Advisors: Dr. Rory P. Remmel, Dr. Timothy S. Tracy

Xin Zhou (PhD), “I. Probing the Catalytic Potential of Tyrosine 190 of the Hamster Arylamine N-Acetyltransferase 2 (NAT2) and Implication of Protein Intracellular Stability II. Catalytic and Kinetic Mechanisms of Human Histidine Triad Nucleotide Binding Protein 1 (Hint1)” Advisor: Dr. Carston R. Wagner

Swapna Bhagwanth (PhD), “Synthetic approaches Toward Azabicyclic and Azaspirobicyclic Scaffolds Relevant to Peptide Conformation Control” Advisor: Dr. Rodney L. Johnson

Hailey L. Gahlon (MS), “Understanding p53 Regulation: Post-Translational Modification Affects at the DNA Binding domain and Binding to its Negative Repressor hDM2” Advisor: Dr. Shana J. Sturla

Melissa M. Goggin (PhD), “Formation, Persistence, and Repair of 1,2,3,4-Diepoxybutane-Induced Bifunctional DNA Adducts in Tissues of Rodents Exposed to 1,3-Butadiene by Inhalation” Advisor: Dr. Natalia Tretyakova

Li Liu (PhD), “Studies on Human Arylamine N-Acetyltransferases” Advisor: Dr. Patrick E. Hanna

Xiaodan (Kathy) Liu (PhD), “Natural Products and their Derivatives in Cancer Prevention and Therapy: Inositol Phosphates and Illudin S” Advisor: Dr. Shana J. Sturla.

Lei Meng (MS), “Quantitation of N2-Ethylidene-dGuo in Human Leukocyte DNA of Singapore Chinese Women and the Effect of Wok Cooking” Advisor: Dr. Stephen S. Hecht

Kathryn E. Pietsch (MS), “Chemical Aspects of Scylfulvene Bioactivation to a Cytotoxic Reactive Intermediate” Advisor: Dr. Shana J. Sturla

Brian R. White (PhD), “Toward Therapeutic Nanoassemblies: The Design and Modeling of Protein-Protein Interactions” Advisor: Dr. Carston R. Wagner

Siyi Zhang (PhD), “Analysis of Pyridyloxobutyl and Pyridylhydroxybuty1 DNA Adducts in Extra-Hepatic Tissues of Rats Treated with Tobacco -Specific Nitrosamines” Advisor: Dr. Stephen S. Hecht

Ranganathan Balasubramanian (PhD), “Part I: Design and synthesis of CYP7B1 Inhibitors for the Chemoprevention of Prostate Cancer," "Part II: Synthesis and Structure-Activity Relationships of Tubulysins” Advisor: Dr. Robert A. Fecik

Jignesh Doshi (PhD), “Rational Design, syntheses, and Biological Evaluation of Antagonists against Anti-Apoptotic Bcl-2 Proteins” Advisor: Dr. Chengguo Xing

Thomas E. Johnson (MS), “Design, Synthesis, and Biological Evaluation of Potential Chemopreventive Agents Against Lung Tumorigenesis” Advisor: Dr. Chengguo Xing

Jolanna Norton (MS), “Synthesis of Nucleoside Analogs for Elucidation of APOBEC3G Cytidine Deaminase Mechanism” Advisor: Dr. Shana J. Sturla

Cory Kending (PhD), “The Design and Synthesis of Constrained AVPI Peptidomimetics” Advisor: Dr. Rodney L. Johnson.

Rachel Loeber (PhD), “DNA-Protein Cross-Linking by Bis-Electrophiles” Advisor: Dr. Natalia Tretyakova.

Sadiya Noor Addo (MS), “Mechanistic Studies of Small Molecule Antagonists of Anti-Apoptotic Bcl-2 Proteins” Advisor: Dr. Chengguo Xing

Jaeson C. Steel (MS), “Progress Towards the Synthesis of the Tubulysins” Advisor: Dr. Robert A. Fecik

Swati S. More (PhD), “Design, Synthesis and Biological Evaluation of Glutathione Peptidomimetics as Components of Targeted Prodrugs and Glyoxalase I Inhibitors” Advisor: Dr. Robert Vince

Ding Lu (PhD), “The Design, Synthesis and Biological Evaluation of Pseudosymmetric HIV-I Protease Inhibitors Featuring Sulfoximine Functionality as a Potential Transition State Mimic” Advisor: Dr. Robert Vince

Upendra Argikar (PhD), “Effects of Age, Induction, Regulation and Polymorphisms on the Metabolism of Antiepileptic Drugs” Advisor: Dr. Rory P. Remmel

Tsui-Fen Chou (PhD), “Histidine Triad Nucleotide Binding Proteins (Hints): Nucleoside Phosphoramidases and Potential Regulators of Aminoacyl – tRNA Synthetases” Advisor: Dr. Carston R. Wagner

David S. Daniels (PhD), “Bivalent Opioid Ligands as Probes for the Investigation of Opioid Receptor Dimerization. Development of Novel Analgesics without Tolerance or Physical Dependence” Advisor: Dr. Philip S. Portoghese

John W. Giraldes (MS), “Substrate Specificity and Affinity Labeling Studies of Polyketide Synthase Thioesterases” Advisor: Dr. Robert A. Fecik

John R. Goodell (PhD), “Synthesis and Evaluation of Heterocyclic Antiviral Agents” Advisor: Dr. David Ferguson

Brian E. Kane (PhD), “Molecular Recognition of G – Protein Coupled Receptor Ligands: Insights into Salvinorin A and Xanomeline” Advisor: Dr. David Ferguson

Yabin Lao (PhD), “Analysis by HPLC – ESI – MS/MS of Pyridyloxobutyl DNA Adducts in F344 Rats Treated with Tobacco – Specific Nitrosamines” Advisor: Dr. Stephen S. Hecht

Bhooma Raghavan (PhD), “Synthesis of 5.6.5 Spiro Bicyclic Lactams and Photoaffinity Labeling Ligands for PLG Binding Site and Stereoseletive Synthesis of α – Substituted γ – Lactams” Advisor: Dr. Rodney L. Johnson

Terry W. Steele (PhD), “Acid Cleavable Alkyl Polyethlenimine Dendrimeric Vectors for Novel Gene Delivery” Advisor: Dr. W. Thomas Shier

Ashish P. Vartak (PhD), “Design and Synthesis of Type – VI β-Turn Mimics of L-Prolyl-Xaa-L-Prolinamide” Advisor Rodney L. Johnson

Jonathan C. T. Carlson (PhD), “Towards Therapeutic Nanoassemblies: Chemically Induced Protein Oligomerization” Advisor: Dr. Carston R. Wagner

Abigail Fisher (PhD), “Photoaffinity Labeling and Conformationally Constrained Analogs of the Dopamine Receptor Modulator L-Prolyl-L-Leucyl-Glycinamide” Advisor: Dr. Rodney L. Johnson

Xingnan Li (PhD), “Synthesis and Biological Evaluations of Conformationally Restrained α, γ-Diketo Acid Analogs and Purine-Containing Mg2+ Chelating Ligands as Inhibitors for HIV Integrase” Advisor: Dr. Robert Vince

Priyanka A Rao (MS), “Analysis of Phenathrene Metabolite by Liquid Chromatography – Tandem Mass Spectrometry” Advisor: Dr. Stephen S. Hecht

Ye Tang (PhD), “Synthesis and Biological Evaluation of Unsaturated Carbo-Acyclic Nucleosides” Advisor: Dr. Robert Vince

Haiqing Wong (PhD), “Studies on Arylamine N-Acetyltransferases” Advisors: Dr. Patrick E. Hanna, Dr. Carston R. Wagner

Hansen L. Wong (PhD), “Tissue-Specific Metabolic Activation of Carcinogenic Nitrosamines” Advisor: Dr. Stephen S. Hecht